Bayesian Decomposition Analysis of Bacterial Phylogenomic Profiles
Ghislain Bidaut1,2, Karsten Suhre2, Jean-Michel
Claverie2, Michael F. Ochs1
1: Fox Chase Cancer
Center, Bioinformatics, Department of Information Science and
Technology, Philadelphia, PA, 19111, USA
2: Structural and Genomic
Information Laboratory, (CNRS UPR2589), 13402 Marseille, France
This page contains supplemental information related to the publication
"Bayesian Decomposition Analysis of Bacterial Phylogenomic Profiles",
submitted to The American Journal of Pharmacogenomics.
ClutrFree is available here
and Bayesian Decomposition here.
Clicking over an image displays a larger version.
1 Generation of the phylogenomic profiles
Generation of the phylogenomic profiles: 1073
mutual homologs of E.coli and M.tuberculosis, have been
selected and scored with BLAST against the genome sequence of 31
bacteria of interest, yielding 1073 profiles of size 31.
2 Results and patterns found in the data
This figure shows a few pattern vectors obtained by BD and
plotted with ClutrFree for a decomposition in k=30 vectors. BD has
revealed the bacterial phylogeny for Actinobacteria, Firmicutes and
other genuses such as Chlamydiae, Rickettsia and Spirochetes. All
Actinobacteria have been grouped in one single pattern and also
separated in many patterns . The thickness of the lines is proportional
to the stability of each bacteria along the tree branch to which it